VESA BIOS Extensions (VBE) is a VESA standard, currently at version 3, that defines the interface that can be used by software to access compliant video boards at high resolutions and bit depths. This is opposed to the "traditional" INT 10h BIOS calls, which are limited to resolutions of 640×480 pixels with 16 colour (4-bit) depth or less. VBE is made available through the video card's BIOS, which installs during boot up some interrupt vectors that point to itself.

Most newer cards implement the more capable VBE 3.0 standard. Older versions of VBE provide only a real mode interface, which cannot be used without a significant performance penalty from within protected mode operating systems. Consequently, the VBE standard has almost never been used for writing a video card's drivers; each vendor has thus had to invent a proprietary protocol for communicating with its own video card. Despite this, it is common that a driver thunk out to the real mode interrupt in order to initialize screen modes and gain direct access to a card's linear frame buffer, because these tasks would otherwise require handling many hundreds of proprietary variations that exist from card to card.

In EFI 1.x systems, the INT 10H and the VESA BIOS Extensions (VBE) are replaced by the EFI UGA protocol. In widely used UEFI 2.x systems, the INT 10H and the VBE are replaced by the UEFI GOP.